Characterisation of novel anti-HIV/tuberculosis natural product analogues.
نویسندگان
چکیده
Non-nucleoside reverse-transcriptase inhibitors (NNRTIs) are one of the key components of antiretroviral drug regimens against human immunodeficiency virus type 1 (HIV-1) replication. (+)-calanolide A, which is purified from the rainforest plant Calophyllum, is an anti-HIV-1/ tuberculosis drug. In our previous study, a library of (+)-calanolide A was constructed and one novel compound 10-chloromethyl-11demethly-12-oxocalanolide A (F18) with improved antiviral activity was identified. This study investigated antiviral breadth, drug-resistance profile, and underlying mechanism of action of F18.
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ورودعنوان ژورنال:
- Hong Kong medical journal = Xianggang yi xue za zhi
دوره 21 Suppl 7 شماره
صفحات -
تاریخ انتشار 2015